Juq-139

JUQ‑139 is a newly designed heterocyclic small‑molecule that combines a 1,3‑benzothiazole core with a fused pyrazolo[1,5‑a]pyridine moiety, functionalized with a sulfonamide‑linked aryl‑alkyl side chain. The compound was conceived through a structure‑based drug‑design (SBDD) campaign targeting the ATP‑binding pocket of the oncogenic kinase (phosphoinositide 3‑kinase alpha). Here we report a convergent synthetic route to JUJ‑139, its physicochemical profiling, in‑vitro kinase inhibition, cytotoxicity against a panel of cancer cell lines, and preliminary in‑vivo efficacy in a xenograft mouse model. JUQ‑139 exhibits sub‑nanomolar affinity for PI3K‑α (K i = 0.42 nM), selective inhibition over the PI3K‑β/δ/γ isoforms (>500‑fold), and potent antiproliferative activity (IC 50 = 12–38 nM) in triple‑negative breast cancer (TNBC) and KRAS‑mutant colorectal cancer (CRC) cell lines. Oral administration (30 mg kg⁻¹ q.d.) in athymic nude mice bearing MDA‑MB‑231 xenografts produced a 78 % tumor growth inhibition (TGI) with no observable toxicity. These data position JUQ‑139 as a promising lead for further preclinical development toward targeted cancer therapy.

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Usually denotes the specific model number, size variation, production batch, or sequential iteration of the base design. Role in Supply Chain and Inventory Management The appeal of JUQ-139 lies in its exploration

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: Scientific research and development projects often use coded identifiers for their studies, experiments, or prototypes. JUQ-139 could be a project code, a sample identifier, or a reference to a particular study. a sample identifier

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Q: Is JUQ-139 associated with hate speech or toxic content? A: Yes, JUQ-139 has been linked to the spread of misinformation, hate speech, and other forms of toxic content. As a result, many online platforms have taken steps to regulate or restrict its use.